Ex Parte Strand et al - Page 6



          Appeal No. 2006-1460                                                        
          Application No. 10/033,315                                                  

          that it occurs along the edge portions of Holl’s layers.                    
               The appellants’ argument regarding independent method claim            
          31 corresponds to the claim 27 argument.  It follows that this              
          argument is unpersuasive for reasons analogous to those set forth           
          immediately above.                                                          
               In light of the foregoing, it is our determination that the            
          Holl reference evinces a prima facie case of anticipation which             
          the appellants have failed to successfully rebut with argument or           
          evidence to the contrary.  We hereby sustain, therefore, the                
          examiner’s Section 102 rejection of claims 1-6, 8-19 and 27-35 as           
          being anticipated by Holl.                                                  
                      THE SECTION 102 REJECTION BASED ON DUBROW                       
               It is the appellants’ contention that the rejection under              
          consideration is improper because “[t]here is no express                    
          disclosure in Dubrow . . . of operative components mounted aboard           
          any such device [i.e., a microfluidic substrate assembly of the             
          type defined by independent claim 1]” (brief, page 19).  This is            
          not correct.  The examiner has accurately explained in his                  
          rebuttal to this contention (and the appellants have not                    
          disagreed with this explanation) that Dubrow discloses a                    
          microfluidic device having operative components such as an                  
          electrical controller and electrodes mounted there aboard as                
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