Ex Parte 5578684 et al - Page 25

            Appeal No. 2006-2247                                                                              
            Reexamination Nos. 90/006,554 and 90/006,894                                                      
        1   Furthermore, Witman teaches that the tertiary amine includes substituted pyridines.               
        2   Polyvinylpyridine, which was known to be oxidizable to an N-oxide as shown in                     
        3   Dunn and as admitted by Dr. Boeckh, is a substituted pyridine.  In re Mayne, 104                  
        4   F.3d 1339, 1343, 41 USPQ2d 1451, 1454 (Fed. Cir. 1997)(“Structural relationships                  
        5   often provide the requisite motivation to modify known compounds to obtain                        
        6   new compounds.”).                                                                                 
        7          As to the “acid” component recited in appealed claim 1, Witman discloses                   
        8   that the reaction medium containing an aqueous solution of hydrogen peroxide                      
        9   may contain an additional solvent (preferably miscible with water) and that, when                 
       10   the amine is a heterocylic amine, the most useful solvents are lower aliphatic                    
       11   carboxylic acids, preferably glacial acetic acid.  (Column 5, line 71 to column 6,                
       12   line 5.)  Accordingly, a person having ordinary skill in the art would have found it              
       13   prima facie obvious to include a suitable amount of glacial acetic acid in the                    
       14   reaction medium of Witman’s Example V as expressly described in the reference.                    
       15          With respect to separately argued claim 5, Witman teaches that “[a]s a                     
       16   general rule, an amount of the catalyst between about 1.0% and about 20%, based                   
       17   on the number of moles of amine reactant charged, will effectively catalyze the                   
       18   reaction between the amine and the hydrogen peroxide” and in “many cases, even                    
       19   less of the catalyst - e.g., as little as 0.1% of the amine on a molar basis - will be            
       20   sufficient...”  (Column 4, lines 69-74.)  The subject matter of appealed claim 5,                 

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