Appeal No. 2006-2378 Page 2
Application No. 10/433,388
,
to yield a compound of formula (IV)
(where R represents a 2,3-dihydroxy-1-propyl group or a 1,3-dihydroxy-2-propyl group),
and then converting the 5-nitro group of the compound of formula (IV) to an amine,
yielding N,N’-substituted 5-amino-1,3-benzenedicarboxamides of formula (I)
.
Id. at page 2.
However, “the compounds of formula (IV), are products that must be handled
with great care, for their characteristic instability.” Id. at page 3.
In order to avoid the problems associated with the unstable intermediate
compounds of formula (IV), the specification discloses that compounds of formula (I)
can be prepared “by direct amidation of a dialkyl ester of 5-amino-1,3-
benzenedicarboxylic acid and that no stability problems do arise in connection with the
dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid or with the 5-amino-N,N’-bis-
substituted-1,3-benzenecarboxamides (I) thus allowing the reaction to be carried out
industrially under widely varying conditions.” Page 4.
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