Ex Parte Donoho et al - Page 2


                  Appeal 2004-1103                                                                                              
                  Application 09/733,387                                                                                        
                          According to appellants (Request, page 2, emphasis removed),                                          
                          [g]iven the scientific evidence of record, there can be no question                                   
                          that those skilled in the art would clearly believe that [a]ppellants’                                
                          sequence is a functional protein, as opposed to the assertion by the                                  
                          [e]xaminer that “there is no sufficient and credible information that                                 
                          indicates the published sequence is truly function GPCR” . . . .                                      
                  In support of this assertion, appellants’ Request raises five points which                                    
                  appellants believe the Board failed to consider in reaching its Decision.  Id.  We                            
                  will take each in turn.                                                                                       
                          1.  Appellants assert (id., emphasis removed) that “[s]equences sharing                               
                  between 90-100% percent identity at the protein level over the entire length of                               
                  the claimed sequence are present in the leading scientific repository for biological                          
                  sequence data (GenBank).”  We note, however, that simply demonstrating that                                   
                  sequences sharing some degree of identify with appellants’ disclosed sequence                                 
                  are known in GenBank does nothing to establish a utility for the invention of claim                           
                  1.  Accordingly, without more, we are not persuaded by this argument.                                         
                          2.  Apparently, recognizing that the GenBank sequence data alone is                                   
                  insufficient to establish a utility for the invention of claim 1, appellants direct                           
                  attention to five post-filing date references (see Brief, Exhibits A-E).  Request,                            
                  page 2.  According to appellants (id.), these references demonstrate that “third                              
                  party scientists” annotated the GenBank sequences as G protein-coupled                                        
                  receptors.                                                                                                    
                          While we would agree that post-filing date references can be used as                                  
                  evidence of the level of ordinary skill in the art at the time of the application,2                           
                  appellants have not demonstrated that at the time of appellants’ claimed                                      
                  invention a person of ordinary skill in the art would have recognized that these                              
                  GenBank sequences demonstrate that appellants’ claimed sequence is a                                          
                  functional G protein-coupled receptor.  At best, appellants have demonstrated                                 
                  that after their filing date, sequences with some degree of similarity to their own                           
                                                                                                                                
                  2 In re Hogan, 559 F.2d 595, 605, 194 USPQ 527, 537 (CCPA 1977) (“This court has approved                     
                  use of later publications as evidence of the state of the art existing on the filing date of an               
                  application.”  (footnote omitted)).                                                                           

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