Ex Parte Esser et al - Page 16


                Appeal 2006-3252                                                                                 
                Application 09/536,728                                                                           

           1           The most relevant compound described in the Stähle patent is a                            
           2    2-(substituted phenyl-imino)-imidazolidine having the formula set out at                         
           3    col. 1:30-35 where R is 2-chloro-4-methyl-5-amino phenyl.  Col. 1:38.  The                       
           4    compound has the structural formula:                                                             
           5                                                                                                     
                                                                     H                                           
                                            H          Cl                                                        
                                                                     N                                           
                                    H3C                      N                                                   
                                                                      N                                          
                                            N          H              H                                          
           6                            H       H                                                                
           7                                                                                                     
           8                                       Formula 7                                                     
           9                                                                                                     
          10                                         York                                                        
          11           York relates to compounds said to be suitable for use in the treatment                    
          12    of glaucoma and ocular hypertension.  Col. 1:5-7.                                                
          13           The York compounds are broadly described as including compounds                           
          14    having the following structure.                                                                  
                                                                    H                                            
                                                      R1                                                         
                                                                    N                                            
                                     R4                     N                                                    
                                                                     N                                           
          15                               R3         R2             H                                           
          16                                       Formula 8                                                     

                                                      16                                                         

Page:  Previous  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  Next

Last modified: September 9, 2013