Ex Parte Wollenberg et al - Page 7


                   Appeal No. 2007-0495                                                                                             
                   Application No. 10/699,510                                                                                       

                   samples representative of a high, medium and low value of the varied factor (p. 6,                               
                   para. 56).                                                                                                       
                           In some cases, the plurality of samples may be 15 or more samples, 20 or more                            
                   samples, 40 or more samples, and even 80 or more samples (p. 6, para. 56).                                       
                           The plurality of samples can be a library of samples (p. 7, para. 57).                                   
                           The library of samples can be a combinatorial library of product mixtures.  For                          
                   example, libraries can comprise product mixtures that are varied with respect to additives                       
                   (p. 7, para. 61).                                                                                                
                           Figures 4A and 4B illustrate data collected for silicone oils of variable viscosities                    
                   (p. 11, para. 94).                                                                                               
                           The samples may be dispensed with any suitable dispensing apparatus, e.g., an                            
                   automated micropipette or capillary dispenser (p. 6, para. 53).                                                  
                           Each sample is dispensed to an individually addressable region on a substrate                            
                   (p. 6, para. 53).                                                                                                
                           A substrate useful in accordance with the invention disclosed in Kolosov is a                            
                   microtiter plate having a plurality of wells (p. 2, para. 21).                                                   
                           Shtein discloses a method and apparatus for depositing organic material on a                             
                   substrate using a carrier gas (p. 1, para. 8).                                                                   
                           According to one embodiment of the invention disclosed in Shtein, the apparatus                          
                   includes a first organic source cell 110, a second organic source cell 120, a dilution                           
                   channel 130, a mixing chamber 140, a nozzle 150, and heating elements 160.  When a                               
                   carrier gas 105 flows through the organic source cells, the organic material is carried by                       
                   the carrier gas and then mixes in the mixing chamber.  The mixture of the organic                                

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