Ex Parte Crabtree et al - Page 2

                Appeal 2007-1040                                                                               
                Application 09/960,708                                                                         
                                             INTRODUCTION                                                      
                      The claims are directed toward methods of inhibiting (a)                                 
                angiogenesis/vascular development in a host (claims 8 and 46) or (b) tumor                     
                growth in a host (claims 15 and 47).  The methods of claims 8 and 15                           
                comprise the single step of systemically administering an effective amount                     
                of a Ca2+/calcineurin/NF-ATc inhibitory agent to the host.  The methods of                     
                claims 46 and 47 comprise the single step of administering an effective                        
                amount of a cyclosporin to the host.  Claims 8, 15, 46, and 47 are                             
                reproduced below:                                                                              
                      8.   A method of inhibiting angiogenesis/vascular development in a                       
                host having a condition associated with unwanted angiogenesis, said method                     
                comprising:                                                                                    
                systemically administering to said host an effective amount of a                               
                Ca2+/calcineurin/NF-ATc inhibitory agent to inhibit angiogenesis/vascular                      
                development in said host having a condition associated with unwanted                           
                angiogenesis.                                                                                  
                      15.   A method of inhibiting tumor growth in a host having a                             
                neoplastic disease condition, said method comprising:                                          
                systemically administering to said host having a neoplastic disease                            
                condition an                                                                                   
                      effective amount of a Ca2+/calcineurin/NF-ATc inhibitory agent to                        
                inhibit tumor growth in said host.                                                             
                      46.  A method of inhibiting angiogenesis/vascular development in a                       
                host having a condition associated with unwanted angiogenesis, said method                     
                comprising:                                                                                    
                      administering to said host an effective amount of a cyclosporin to                       
                      inhibit angiogenesis/vascular development in a host having a                             
                      condition associated with unwanted angiogenesis.                                         

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