Ex Parte Ashkenazi et al - Page 5

                Appeal  2007-1149                                                                            
                Application  10/066,273                                                                      

                induced angiogenesis would be beneficial including, for example, wound                       
                healing” (Specification 142).                                                                
                      Section 101 requires a utility that is both substantial and specific.  A               
                substantial utility requires “show[ing] that an invention is useful to the                   
                public as disclosed in its current form, not that it may prove useful at some                
                future date after further research.  Simply put, to satisfy the ‘substantial’                
                utility requirement, an asserted use must show that that claimed invention                   
                has a significant and presently available benefit to the public.”  In re Fisher,             
                421 F.3d 1365, 1371, 76 USPQ2d 1225, 1230 (Fed. Cir. 2005).  A specific                      
                utility is “a use which is not so vague as to be meaningless.”  Id.  In other                
                words, “in addition to providing a ‘substantial’ utility, an asserted use must               
                also show that [the] claimed invention can be used to provide a well-defined                 
                and particular benefit to the public.”  Id.                                                  
                      “[T]he PTO has the initial burden of challenging a presumptively                       
                correct assertion of utility in the disclosure.  Only after the PTO provides                 
                evidence showing that one of ordinary skill in the art would reasonably                      
                doubt the asserted utility does the burden shift to the applicant to provide                 
                rebuttal evidence sufficient to convince such a person of the invention’s                    
                asserted utility.”  In re Brana, 51 F.3d 1560, 1566, 34 USPQ2d 1436, 1441                    
                (Fed. Cir. 1995) (citation omitted).                                                         
                      In this case, we agree with Appellants that the Examiner has not                       
                provided a sufficient basis to challenge the Specification’s assertion of                    
                utility.  We agree with the Examiner that the art demonstrates that a variety                
                of stimuli may activate c-fos and that not all of these stimuli are necessarily              
                involved in cancer or pathogenic angiogenesis.  In particular, it is not clear               


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