Appeal 2007-1163
Application 10/172,470
communication with a dispensing station for said wash reagent, a separate
inlet for a reagent for conducting a step of said synthesis in fluid
communication with a dispensing station for said reagent, and a separate
vent,
(c) a vacuum source in fluid communication with said flow cell
chamber, and
(d) a controller communicating with a computer comprising
software to control said vent and said vacuum source to simultaneously vent
and apply vacuum to the flow chamber.
24. A flow cell assembly according to Claim 23 further comprising
a fluid level sensor and a controller for controlling said inlets.
26. An apparatus for synthesizing an array of biopolymers on the
surface of a support, said apparatus comprising:
(a) one or more flow cell assemblies of Claim 23,
(b) one or more fluid dispensing stations in fluid communication
with said one or more flow cell assemblies,
(c) a station for monomer addition to said surface of said support,
and
(d) a mechanism for moving a support to and from said station for
monomer addition and a flow cell and from one flow cell to another flow
cell.
28. An apparatus according to Claim 26 wherein said mechanism is
a robotic arm.
Thus, claim 23 is directed to a flow cell assembly comprising a flow
cell chamber, a manifold, a vacuum source, and a controller. The manifold
comprises a wash reagent inlet, a separate inlet for another reagent, and a
separate vent. The controller “communicat[es] with a computer comprising
software to control [the] vent and [the] vacuum source to simultaneously
vent and apply vacuum to the flow chamber.” We interpret this recitation to
require that the vent be open while the vacuum is applied.
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