Ex Parte Graf et al - Page 5

               Appeal  2007-2018                                                                            
               Application  09/810,377                                                                      

               FEP “is a known equivalent plastic that is used with catheters provided with                 
               varying amounts of radiopaque materials” and “is a material having more                      
               lubricious properties which would allow for easier insertion” (id. at 3).                    
                      We conclude that the Examiner has set forth a prima facie case of                     
               obviousness.  Parker describes a “guiding catheter having a main tubular                     
               portion and a soft tip” with “matching external and internal tapers for                      
               increasing the contact area of the thermal bond” (Parker, col. 1, ll. 55-56,                 
               and Abstract).  “The main tubular portion includes a layered wall . . .                      
               advantageously includ[ing] an inner material layer . . . and an outer material               
               layer” (id. at col. 1, ll. 61-67).  The inner layer preferably comprises                     
               polytetrafluoroethylene and the outer layer “preferably comprises polyether                  
               block amide including by weight 10 to 30 percent radiopaque bismuth” (id.                    
               at col. 2, ll. 24-33).  The soft tip “comprises another polyether block amide                
               . . . and advantageously includes by weight 35 to 65 percent tungsten for                    
               increasing the radiopacity of the soft tip” (id. at col. 2, ll. 34-40).                      
                      Coneys describes a catheter including an extruded tube of flexible                    
               material comprising a plastic material, preferably polyfluorinated                           
               ethylenepropylene, and “an integrally extruded radiopaque layer 14                           
               completely embedded within and surrounded by the plastic material”                           
               (Coneys, col. 3, ll. 16-32).  “The radiopaque layer 14 comprises a blended                   
               mixture of radiopaque material and a binder material,” which “may be the                     
               same plastic material as the virgin or pure plastic material” that surrounds                 
               the radiopaque layer (id. at col. 3, ll. 35-45).  The radiopaque material may                
               be bismuth trioxide or tungsten powder (id. at col. 3, ll. 47-49).                           



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