Ex Parte EL-Naggar et al - Page 4

                 Appeal 2007-2834                                                                                      
                 Application 09/943,048                                                                                

                 individually used for the treatment of arthritis,” the Examiner concludes that                        
                 it would have been obvious to combine those ingredients, “each of which is                            
                 taught by [the] prior art to be useful for same purpose; [the] idea of                                
                 combining them flows logically from their having been individually taught                             
                 in the prior art.  The combination of active ingredient with the same                                 
                 character is merely the additive effect of each individual component” (id. at                         
                 7, citing In re Kerkhoven, 626 F.2d 846, 850 (CCPA 1980)).                                            
                        Appellants argue that the cited combination of references fails to                             
                 demonstrate the claims’ obviousness because Langhoff discloses that low                               
                 dose aspirin has an anti-arthritis benefit only when co-administered with an                          
                 ω-3-unsaturated fatty acid, vitamin E, and vitamin C (Br. 9-14),1 and                                 
                 because “Shapiro teaches that the disclosed flavonoids, flavanoids and                                
                 isoflavones as antioxidants are useful in treating [] inflammatory disease                            
                 only in combination with carbonyl trapping agents” (id. at 20).                                       
                        As stated in In re Oetiker, 977 F.2d 1443, 1445-1446 (Fed. Cir. 1992):                         
                        [T]he examiner bears the initial burden, on review of the prior                                
                        art or on any other ground, of presenting a prima facie case of                                
                        unpatentability. If that burden is met, the burden of coming                                   
                        forward with evidence or argument shifts to the applicant.                                     
                               . . . .                                                                                 
                        [T]he  conclusion  of  obviousness vel  non  is  based  on  the                                
                        preponderance of evidence and argument in the record.                                          
                        The test of obviousness is “whether the teachings of the prior art,                            
                 taken as a whole, would have made obvious the claimed invention.”  In re                              
                 Gorman, 933 F.2d 982, 986 (Fed. Cir. 1991).  Thus, “‘[i]t is impermissible                            

                                                                                                                      
                 1 Appeal Brief filed (August 29, 2006).                                                               

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