Ex Parte Gardner et al - Page 8

                Appeal 2007-2956                                                                              
                Application 10/677,733                                                                        
                the gating of the HERG K+ channels through the binding of small molecule                      
                or protein effectors” (id., at 854, col. 2).  Thus, despite having a tightly                  
                packed core with no pre-formed cavity, in view of its similarity to other PAS                 
                domain proteins, Morais Cabral suggested that small molecules might                           
                regulate eag domain activity as they do for other PAS domains.                                
                      In sum, we conclude that Appellants did not sustain their burden in                     
                rebutting the case of prima facie obviousness of claim 1.  The rejection is                   
                affirmed.                                                                                     
                                               TIME PERIOD                                                    
                      This decision contains a new ground of rejection pursuant to 37                         
                C.F.R. § 41.50(b) (effective September 13, 2004, 69 Fed. Reg. 49960                           
                (August 12, 2004), 1286 Off. Gaz. Pat. Office 21 (September 7, 2004)).  37                    
                C.F.R. § 41.50(b) provides “[a] new ground of rejection pursuant to this                      
                paragraph shall not be considered final for judicial review.”                                 
                      37 C.F.R. § 41.50(b) also provides that the Appellant, WITHIN TWO                       
                MONTHS FROM THE DATE OF THE DECISION, must exercise one of                                    
                the following two options with respect to the new ground of rejection to                      
                avoid termination of the appeal as to the rejected claims:                                    
                             (1) Reopen prosecution. Submit an appropriate                                    
                      amendment of the claims so rejected or new evidence relating                            
                      to the claims so rejected, or both, and have the matter                                 
                      reconsidered by the Examiner, in which event the proceeding                             
                      will be remanded to the Examiner. . . .                                                 
                             (2) Request rehearing. Request that the proceeding be                            
                      reheard under § 41.52 by the Board upon the same record. . . .                          
                                                                                                             
                      Should the Appellants elect to prosecute further before the Examiner                    
                pursuant to 37 C.F.R. § 41.50(b)(1), in order to preserve the right to seek                   


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