Ex parte CARTER et al. - Page 4




                Appeal No. 95-0777                                                                                                            
                Application 07/756,411                                                                                                        


                render obvious a method for making the claimed compounds.  As                                                                 
                stated by the court in In re Hoeksema :                       3                                                               
                                 Thus, upon careful reconsideration it is our view that                                                       
                                 if the prior art of record fails to disclose or render                                                       
                                 obvious a method for making a claimed compound, at the                                                       
                                 time the invention was made, it may not be legally                                                           
                                 concluded that the compound itself is in the possession                                                      
                                 of the public [footnote omitted].  In this context, we                                                       
                                 say that the absence of a known or obvious process for                                                       
                                 making the claimed compounds overcomes a presumption                                                         
                                 that the compounds are obvious, based on close                                                               
                                 relationships between their structures and those of                                                          
                                 prior art compounds.                                                                                         
                See also In re Payne, 606 F.2d 303, 314-15, 203 USPQ 245, 255                                                                 
                (CCPA 1979), and In re Brown, 329 F.2d 1006, 1011, 141 USPQ 245,                                                              
                249 (CCPA 1964).  References relied upon to support a rejection                                                               
                under 35 U.S.C. § 103 must provide an enabling disclosure, i.e.,                                                              
                they must place the claimed invention in the possession of the                                                                
                public.  In re Payne, 606 F.2d at 314, 203 USPQ at 255.                                                                       
                         Appellants argue that there is no known way to make the                                                              
                substitution proposed by the examiner (brief, page 7).                                                                        
                Appellants cite evidence from Carter II and U.S. Patent No.                                                                   
                5,077,277 (of record) that the proposed methods of preparing the                                                              
                claimed compounds, as suggested by the examiner, would not result                                                             
                in the claimed compounds (see page 8 of the brief).                                                                           


                         3399 F.2d 269, 274, 158 USPQ 596, 601 (CCPA 1968).                                                                   
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