Appeal No. 93-3114
Application 07/825,465
adjuvant and gentamicin (30 ug/ml) . . . was added
as a preservative (Oden et al, 1974).
In Chapter IV, “The Immune Response of Cattle to Fusobacterium
Necrophorum,” at page 148, first full paragraph, Maas states:
The purpose of the present study was i) to determine
if leukotoxin neutralizing activity was present in bovine
sera after immunization with 2 F. necrophorum vaccine
preparations or experimental F. necrophorum
infection
and ii) to evaluate the effect of these vaccines or
infection on the peripheral blood lymphocyte
response.
At page 151, last paragraph, Maas states (emphasis added):
A whole-cell (FN 3080 WC) and a RRE (FN 3080
RRE) vaccine were prepared for immunization of calves.
The whole-cell vaccine was prepared as described in
Chapter III.
See Group III of Table 1. Experimental design of bovine F.
necrophorum immunological study, page 153. “An experimental
infection with F. necrophorum isolate FN 3080 was induced in
the group II, III, and IV calves 7 days after the last
immunization (Table 1)” (pages 152 & 154, bridging sentence).
The experiments were designed (page 170, last full sentence):
. . . to determine if, after specific immunization
or infection, leukotoxin neutralizing activity and
transformed lymphocytes were present which may
contribute to effective antitoxic and cellular
immunity to F. necrophorum infections in cattle.
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