Appeal No. 93-4005
Application 07/795,158
could cause catabolic repression of enzyme synthesis" (id.) at
1124, end of col. 2. In other words, the optimum time for
permitting autolysis to occur must be determined.
40. A first publication of Lahoz et al. reveals that
"[i]t is well known that the autolytic phase of growth in
filamentous fungi is a degration [sic-degradation] process
carried out to a great extent by lytic enzymes produced by the
same fungi." Lahoz et al., "Lytic Enzymes in the Autolysis of
Filamentous Fungi," 60 Mycopathologia 45 (1976).
41. Another publication of Lahoz et al. reveals that
autolysis of filamentous fungi is influenced by external
variables. Lahoz et al., "Effect of the pH on the degree of
autolysis of Aspergillus niger," 67 Can. J. Bot. 1901 (1979).
Among those external influences are (1) the nature of the
nitrogen source, (2) culture conditions, (3) addition of
antibiotics or vitamins, (4) temperature, (5) carbon source
concentration and, as the article describes, the pH value
during autolysis. Id.
B. Discussion
1. The examiner's rejection
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