Ex parte COOPER et al. - Page 3




          And Appeal No 94-1146                                                       
          Application 07/746,050                                                      
          isolated from soil collected in Uruguay (Spec., p. 3, last                  
          paragraph).                                                                 
          2.   The rejections                                                         
               A.   Claims 1-12 stand rejected under 35 U.S.C. § 103 as               
          being unpatentable in view of antibiotic AB-85 disclosed in                 
          Japanese Patent Publication 59-18035, published April 25,                   
          1984.                                                                       
               B.   Claims 1-12 stand provisionally rejected for                      
          obviousness-type double patenting of Claims 1-9 of commonly                 
          assigned copending Application 07/747,456.                                  
               C.   Claims 1-12 stand provisionally rejected for                      
          obviousness-type double patenting of Claims 1-9 and 11 of                   
          commonly assigned Application 07/746,059.                                   
          3.   Discussion                                                             
               A.   Obviousness under Section 103                                     
               The examiner has the initial burden of making out a case               
          for obviousness under 35 U.S.C. § 103.  Here, the examiner’s                
          case for obviousness is supported by the following arguments                
          (Examiner’s Answer, pp. 3-4):                                               
                    The Japanese patent discloses an antibiotic                       
               having molecular formula C H N O .  Appellants on                      
                                         25282 5                                      
               page 13 of the specification state that the macrolactam                
               monosaccharide of formal [sic, formula] 2 and having                   
               the molecular formula as given, is disclosed by the                    
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