Ex parte FLYNN et al. - Page 8




          Appeal No. 94-3351                                                          
          Application 07/919,679                                                      


          and King at column 7, lines 38 through 54), albeit neither Watts            
          nor King specifically indicates that these prior art compounds              
          exhibit 5-HT  agonist activity, as possessed by some of the                 
                      4                                                               
          compounds covered by the appealed claims.  In this regard, on               
          remand, the examiner should indicate why appellants’ finding at             
          paragraphs 4.6 and 4.7 of the Flynn declaration that a compound             
          covered by the appealed claims exhibits approximately 3.5 times             
          more 5-HT  agonist activity than the preferred compound of Watts            
                   4                                                                  
          would not have been unexpected to a person of ordinary skill in             
          this art.  Compare In re Chupp, 816 F.2d 643, 646, 2 USPQ2d 1437,           
          1439, (Fed. Cir. 1987) wherein the court held that evidence that            
          a compound is unexpectedly superior in one of a spectrum of                 
          common properties can be enough to rebut a prima facie case of              
          obviousness.                                                                
               The examiner should also consider, on remand, whether or not           
          the comparative showing in the Flynn declaration, which is                  
          limited to a single compound covered by the claims (a salt having           
          0.4 H O), is reasonably commensurate in scope with any claim                
               2                                                                      
          presented on appeal.                                                        
               On remand to the examiner, the examiner should consider                
          whether there is any factual support for rejection of the                   
          appealed claims based on the relied upon prior art references               

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