Ex parte CHAMBERLIN et al. - Page 4




                     Appeal No. 96-0009                                                                                                                                                
                     Application 08/104,417                                                                                                                                            


                     § 112, first paragraph, see In re Brana, 51 F.3d 1560, 1564 n.                                                                                                    
                     12, 34 USPQ2d 1436, 1439 n.12 (Fed. Cir. 1995); In re Jolles,                                                                                                     
                     628 F.2d 1322, 1326 n.10, 206 USPQ 885, 889 n.11 (CCPA 1980);                                                                                                     
                     In re Fouche, 439 F.2d 1237, 1243, 169 USPQ 429, 434 (CCPA                                                                                                        
                     1971), we address both the issues of utility and enablement.                                                                                                      
                                Appellants point out that the claimed invention is                                                                                                     
                     directed toward a method for inhibiting the L-glutamate                                                                                                           
                     neurotransport system and not toward a method for treating                                                                                                        
                     disorders of central nervous systems in humans, and argue that                                                                                                    
                     in their method, as stated in their specification (page 5,                                                                                                        
                     lines 6-14), specific inhibitors of L-glutamate uptake provide                                                                                                    
                     useful probes for evaluating the role of the transport system                                                                                                     
                     in neurotransmission (brief, pages 15 and 18).  As evidence                                                                                                       
                     that the claimed invention has the asserted utility,                                                                                                              
                     appellants rely upon their specification, the second                                                                                                              
                     declaration of Dr. Richard Bridges, filed on March 14, 1994,                                                                                                      
                     and an advertisement newsletter by the British company Tocris                                                                                                     
                     Neuramin.2                                                                                                                                                        


                                2 The Tocris Neuramin advertisement newsletter states that                                                                                             
                     L-trans-pyrrolidine-2,4-dicarboxylic acid inhibits L-glutamate                                                                                                    
                     uptake into synaptosomes, but provides no supporting data.                                                                                                        
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