Ex parte ROSE et al. - Page 11




          Appeal No. 96-3923                                                          
          Application 08/309,790                                                      


               Considering next the rejections under 35 U.S.C. § 103 of               
          claims 1 and 5-7 based on the combined teachings of Fuller and              
          Rose and claims 1-4 based on the combined teachings of Fuller               
          and Ray, each of these claims is directed to a method for                   
          reducing the incidence of tobacco by simulating respiratory                 
          tract sensations in a user substantively similar to those                   
          obtained by inhalation of tobacco smoke.  The answer states                 
          that:                                                                       

                         Fuller describes an experiment wherein                       
                    capsaicin, an extract, or constituent, of                         
                    pepper, was inhaled by human subjects (see                        
                    page 1080, column 1, first (abstract)                             
                    paragraph and column 2, paragraph beginning                       
                    "Drug Delivery" in particular).  The device                       
                    used was a nebulizer.  This is the same                           
                    method as here claimed.  [Page 3.]                                

          Thereafter, the examiner concludes that it would have been                  
          obvious (1) "to have used the aerosol device of Rose in order               
          to deliver the capsaicin to the human subjects" (answer, page               
          4) and (2) "to have used the tube of Ray as the nebulizer in                
          the method of Fuller, substituting capsaicin for nicotine, in               
          order to deliver the capsaicin to human subjects" (answer,                  
          page 4).                                                                    

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