Ex parte ORLOWSKI et al. - Page 6




                   Appeal No. 1995-4370                                                                                                                             
                   Application 07/401,432                                                                                                                           


                   would lead one skilled in the art to substitute amide bridges of the particular structure                                                        
                   required by the claims for the disulfide binds of the prior art analogs.                                                                         
                            It is well settled that the initial burden of establishing unpatentability rests on the                                                 
                   examiner.  In re Oetiker, 977 F.2d 1443, 1446, 24 USPQ2d 1443, 1445 (Fed. Cir. 1992).                                                            
                   Moreover, 35 U.S.C. § 103 requires that obviousness be determined on the basis of the                                                            
                   claimed “subject matter as a whole.”  Here, the examiner’s decisional process did not                                                            
                   begin with a fact-based analysis of what was being claimed.  The inevitable result was that                                                      
                   the examiner’s conclusion of obviousness was based on less than the entire claimed                                                               
                   subject matter.  Accordingly, we find that the examiner’s initial burden of establishing a                                                       
                   prima facie case of obviousness has not been met, and the                                                                                        
                                                                                                                         2                                          
                   rejection of claims 29, 30, 86 and 87 under 35 U.S.C. § 103 is reversed.                                                                         
                                                                         REVERSED                                                                                   

                                                                                                          )                                                         
                                                         William F. Smith                                 )                                                         
                                                         Administrative Patent Judge                      )                                                         
                                                                                                          )                                                         
                                                                                                          ) BOARD OF PATENT                                         
                                                         Joan Ellis                                       )                                                         
                                                         Administrative Patent Judge                      )   APPEALS AND                                           
                                                                                                          )                                                         
                                                                                                          ) INTERFERENCES                                           

                            2Having determined that a prima facie case of obviousness has not been                                                                  
                   established, we do not find it necessary to comment on appellants’ arguments at pages 7                                                          
                   through 13 of the Brief regarding unexpected results attributable to the present invention.                                                      
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