Ex parte PECK et al. - Page 4




              Appeal No. 1996-2790                                                                                       
              Application 08/102,176                                                                                     



                                                     DISCUSSION                                                          
              1.  Enablement                                                                                             
                     In stating the rejection at page 2 of the Examiner's Answer, the examiner first                     
              indicates that “the disclosure is enabling only for claims limited as shown below.”  What                  
              appears “below” is the following paragraph:                                                                
                            A method is claimed, decreasing or blocking passage of bioactive                             
                     and toxic compounds by applying a compound shown to increase and toxic                              
                     compounds by applying a compound shown to increase passage of                                       
                     bioactive and toxic compounds.  There is no presentation of the conditions,                         
                     concentrations, compounds or adjuvants required to permit one of ordinary                           
                     skill in the art to practice this method on living mammals with expectation of                      
                     the claimed results, yet prior art shows this method with this compound                             
                     results in penetration (Rajadhyaksha, compound 27).                                                 
              In reading the paragraph which appears “below,” it is not clear how the examiner would                     
              have appellants limit the claims.  The paragraph is all but incomprehensible.                              
                     If we were to make an educated guess as to what is concerning the examiner, it                      
              would be that Rajadhyaksha describes the compounds which are used in the claimed                           
              method as increasing, rather than decreasing, passage of active agents through the skin                    
              of a mammal.  In other words, Rajadhyaksha states that the compounds set forth in claims                   
              46-49 operate in a manner opposite that claimed.                                                           
                     In considering this issue, we first note that the claims on appeal are limited to the               
              use of fifteen compounds, i.e., N-[(C -C ) straight chain acyl]-2-oxazolidiones.                           
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