Appeal No. 1997-3945
Application No. 08/410,390
DECISION ON APPEAL
This appeal was taken from the examiner's decision
rejecting claims 1 through 4 and 17 through 20. Claims 5, 8
through 16, 21, and 24, which are the only other claims
remaining in the application, stand withdrawn from further
consideration by the examiner as directed to a non-elected
invention. Claims 1 and 17 are illustrative of the subject
matter on appeal and read as follows:
1. An immunoconjugate coupled through the avidin-biotin
interaction, comprising an internalizable cell binding
component having a biotin-binding element conjugated to a
biotinylated moiety, wherein said biotinylated moiety is
selected from the group consisting of cytotoxic proteins and
nucleic acids, wherein said protein is selected from the group
consisting of gelonin, ricin, saporin, abrin, diptheria toxin,
psuedomonas [sic] exotoxin, rayalase, superoxide dismutase,
protein tyrosine phosphatase, protein phosphatase (PP-1 or PP-
2), protein kinase A and protein kinase C.
17. A method of delivering a cytotoxic moiety to a cell
comprising the administration of an immunoconjugate coupled
through the avidin-biotin interaction to a human, wherein said
immunoconjugate comprises an internalizable cell binding
component having a biotin-binding element conjugated to a
biotinylated moiety, wherein said biotinylated moiety is
selected from the group consisting of cytotoxic proteins and
nucleic acids, wherein said protein is selected from the group
consisting of gelonin, ricin, saporin, abrin, diptheria toxin,
psuedomonas [sic] exotoxin, rayalase, superoxide dismutase,
protein tyrosine phosphatase, protein phosphatase (PP-1 or PP-
2), protein kinase A and protein kinase C.
The references relied on by the examiner are:
-2-
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