Appeal No. 1997-3945
Application No. 08/410,390
considered appellants' specification and claims, the applied
references, and the respective positions articulated by
appellants and the examiner. In our judgment, some, but not
all, of the references cited by the examiner are relevant.
Under these circumstances, we reverse the examiner's rejection
of claims 1 through 4 on procedural grounds and we enter a new
ground of rejection of those claims under the provisions of
37 CFR § 1.196(b).
Claims 1 through 4 are rejected under 35 U.S.C. § 103 as
unpatentable over the combined disclosures of Goodwin,
Pastan '985, and Pastan (Cell).
The claimed invention is directed to an immunoconjugate
coupled through the avidin-biotin interaction, comprising an
internalizable cell binding component having a biotin-binding
element conjugated to a biotinylated moiety. The biotinylated
moiety is selected from the Markush group of cytotoxic
proteins and nucleic acids, wherein the cytotoxic protein is
further selected from the group consisting of gelonin, ricin,
saporin, abrin, diptheria toxin, pseudomonas exotoxin,
rayalase, superoxide dismutase, protein tyrosine phosphatase,
protein phosphatase (PP-1 or PP-2), protein kinase A and
-5-
Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Next
Last modified: November 3, 2007