Ex parte LIGLER et al. - Page 3




                     Appeal No. 1995-4188                                                                                                                                              
                     Application 07/860,965                                                                                                                                            


                                the outlet port; and                                                                                                                                   
                                           a flow mean adapted for flowing liquid through the                                                                                          
                     bed                   at a rate of 0.1 to 2.0 ml/min, thereby providing a                                                                                         
                     target                molecule in said sample insufficient time in the                                                                                            
                     vicinity of                     said said antigen-binding site and said labelled                                                                                  
                     antigen for                     equilibration.                                                                                                                    





                                                                            THE REFERENCES                                                                                             
                     Gray et al. (Gray)             4,277,560           Jul. 7,                                                                                                        
                     1981                                                                                                                                                              
                     Enzyme-Immunoassay 224-33, 243, 289 (Edward T. Maggio, ed.,                                                                                                       
                     CRC Press 1980) (Maggio).                                                                                                                                         
                                                                            THE REJECTIONS                                                                                             
                                The claims stand rejected under 35 U.S.C. § 103 as                                                                                                     
                     follows: claims 40, 42, 45, 50-53 and 56-63 over Maggio,  and                                                            1                                        
                     claims 43 and 44 over Maggio in view of Gray.2                                                                                                                    


                                1The examiner withdrew the rejection of claim 47 in the                                                                                                
                     supplemental answer (page 4) and indicated that this claim is                                                                                                     
                     objected to as being dependent upon a rejected base claim, but                                                                                                    
                     would be allowable if rewritten in independent form including                                                                                                     
                     all of the limitations of the base claim and any intervening                                                                                                      
                     claims.                                                                                                                                                           
                                2The examiner states in the supplemental answer (page 2)                                                                                               
                     that claim 46 is rejected.  This claim, however, has been                                                                                                         
                     canceled (amendment filed October 18, 1993, paper no. 11,                                                                                                         
                                                                                          3                                                                                            





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