Ex parte LIGLER et al. - Page 6




          Appeal No. 1995-4188                                                        
          Application 07/860,965                                                      


          antigen in the sample and the labeled antigen (page 225).  The              
          dissociation renders the immunosorbent ready for another                    
          assay.  See id.  The examiner has not explained, and it is not              
          apparent, why the relied-upon portion of Maggio is a                        
          disclosure of labeled antigen saturating the antigen-binding                
          sites of the antibody as required by appellants’ claims.                    
               The examiner argues that Maggio’s statement on page 224                
          that “[t]he system can also be used to perform other types of               
          immunoassay, for example, sandwich methods and techniques that              
          involve a second antibody bound to solid phase” describes                   
          appellants’ displacement system (answer, page 7).  The                      
          relevance of this portion of the reference to displacement,                 
          however, is not explained by the examiner and is not apparent.              
               The examiner does not rely upon Gray for any disclosure                
          which remedies the above-discussed deficiency in Maggio.                    
               For the above reasons, we find that the examiner has not               
          set forth a factual basis which is sufficient for supporting a              
          conclusion of obviousness of the invention recited in any of                
          appellants’ claims.  We therefore reverse the examiner’s                    
          rejections.                                                                 


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