Appeal No. 1996-3326
Application No. 08/063,067
the Supplemental Reply Brief dated Mar. 24, 1995, page 6).
The examiner has also not answered appellant’s contention that
the data in Kwon shows there is a reservoir of
tetrahydrobiopterin in uninduced macrophages which is greater
than that necessary for producing maximal generation of nitric
oxide, thus leading away from inhibiting the induction of
tetrahydrobiopterin to reduce nitric oxide synthesis
(Supplemental Reply Brief, page 2).
The other primary references to Rees and Salvemini do not
remedy the deficiencies noted above with regard to Kwon. Rees
is directed to the blocking of NO production by L-NMMA while
Salvemini, like Kwon, is directed to macrophages, teaching
that L-NMMA “probably inhibits NO formation from L-arginine.”
(See the Answer, page 5).
The examiner finds that the secondary references to
Spada, Nichol and Austel “teach various pterion analogs and
homologs as useful for treating various cardiac conditions to
include hypotension.” (Answer, page 5). We agree with
appellant (Brief, pages 24-25) that this finding is an
overgeneralization. The compounds of Austel lower blood
pressure (column 12, lines 17-22) which is the opposite effect
5
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