Appeal No. 1996-3326
Application No. 08/063,067
APPENDIX
Claim 1. A method of prophylaxis or treatment of a subject
for systemic hypotension caused by pathological overproduction
of nitric oxide from arginine induced in vascular smooth
muscle cells in said subject by therapy of said subject with a
cytokine, said method comprising administering to said subject
of a therapeutically effective amount of (a) at least one
guanosine triphosphate pathway tetrahydrobiopterin synthesis
antagonist which is not a reduced pterin that is a substrate
for the pterin salvage pathway or (b) at least one
dihydrofolate reductase inhibitor or both (a) and (b), thereby
to inhibit nitric oxide synthesis in said cells to ameliorate
said hypotension.
Claim 6. A method of treatment of a subject for systemic
hypotension or expected systemic hypotension caused by
pathological overproduction of nitric oxide from arginine
induced in vascular smooth muscle cells in said subject by
bacterial endotoxins, said method comprising administering to
said subject of a therapeutically effective amount of (a) at
least one guanosine triphosphate pathway tetrahydrobiopterin
synthesis antagonist which is not a reduced pterin that is a
substrate for the pterin salvage pathway or (b) at least one
dihydrofolate reductase inhibitor or both (a) and (b), thereby
to inhibit nitric oxide synthesis in said cells to ameliorate
said hypotension.
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