Appeal No. 1997-2795
Application No. 08/438,933
chemical sulfation step is not performed prior to periodate oxidation of the bovine heparin starting
material .
The references relied on by the examiner are:
Naggi et al. (Naggi ‘063) 4,727,063 Feb. 23, 1988
Naggi et al. (Naggi ‘881) 4,948,881 Aug. 14, 1990
Petitou et al. (Petitou) 5,013,724 May 7, 1991
(filed Jul. 11, 1986)
Casu et al. (Casu), “Retention of Antilipemic Activity by Periodate-oxidized Non-anticoagulant
Heparins,” Vol. 36 (I), Arzneimittel-Forschung/Drug Research, No. 4,
pp. 637-42 (1986).
Fransson et al. (Fransson (M)), “Periodate Oxidation and Alkaline Degradation of Heparin-
Related Glycans,” Vol. 80, Carbohydrate Research, pp. 131-45 (1980).
The Merck Index (Merck), “An Encyclopedia Of Chemicals, Drugs, and Biologicals,” page
795:4685 (Budavari et al. eds., 12th ed., Merck & Co., Inc., Whitehouse Station, NJ, 1996). 2
Appellants rely on the following reference supplied with their brief:
“Biosynthesis of heparin and related polysaccharides” in HEPARIN, page 164 (Lane et al. eds.,
Chemical and Biological Properties Clinical Applications ed., Edward Arnolds, London, 1989)
(Heparin).
Merck was newly supplied by the examiner with the answer “in support of the examiner’s position in the2
existing grounds of rejection” (Paper No. 9, page 4).
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