Appeal No. 1997-3542
Application No. 08/192,507
Claims 1, 3 and 14 are illustrative of the claims on appeal and reads as follows:
1. An anti-IgM antibody conjugate comprising:
a monoclonal antibody which binds selectively to IgM antibody, does not bind to IgG or
1
IgG antibody, has a G isotype; and a cytotoxic moiety conjugated to aid monoclonal
2
antibody.
3. The conjugate of claim 1, wherein said monoclonal antibody is produced by
a hybridoma named 2G10.
14. The conjugate of claim 11, wherein said monoclonal antibody is either
produced by the 1C2 hybridoma.
The prior art references of record relied upon by the examiner in rejecting the
appealed claims are:
Julius et al. (Julius), “Induction of resting B cells to DNA synthesis by soluble monoclonal
anti-immunoglobulin,” Eur. J. Immunol. Vol. 14, pp. 753-757 (1984).
Kung et al. (Kung), “A Mouse IgM Allotypic Determinant (Igh-6.5) Recognized by A
Monoclonal Rat Antibody,” The Journal of Immunology, Vol. 127, No. 3, pp. 873-876
(1981).
Lambert et al. (Lambert), “Purified Immunotoxins That Are Reactive with Human Lymphoid
Cells,” The Journal of Biological Chemistry, Vol. 260, No. 22, pp.1203512041 (1985).
Taylor et al. (Taylor), “Redistribution and Pinocytosis of Lymphocyte Surface
Immunoglobulin Molecules Induced by Anti-Immunoglobulin Antibody,” Nature New Biology,
Vol. 233, pp.225-229 (1971).
DeClercq et al. (DeClercq), “Generation of Rat - Rat Hybridomas with the Use of the LOU
IR983F Nonsecreting Fusion Cell Line,” Methods in Enzymology, Vol. 121, pp. 234-238
(1986).
Brady et al. (Brady), “Therapeutic and Diagnostic Uses of Modified Monoclonal
Antibodies,” L.J. Radiation Oncology Biology Physics, Vol. 13, No. 10, pp.1535-1544
(1986).
2
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