Ex parte ROSENBLUM et al. - Page 6




              Appeal No. 1997-3542                                                                                       
              Application No. 08/192,507                                                                                 


                     Thus, the burden shifts to the appellants to rebut the prima facie case of lack of                  
              enablement established by the examiner.  Appellants respond to this rejection by                           
              indicating that the 2G10 cell line was deposited with the ATCC on April 23, 1990 and was                   
              given Deposit Accession No. ATCC HB 10436.   Appellants do not provide arguments or                        
              evidence as to why a deposit of 2G10 and IC2 are not required.                                             
                     As acknowledged by the examiner, the appellants have failed to provide sufficient                   
              assurances that the required deposit has been made and all the conditions of 37 CFR §                      
              1.801-1.809 have been met.  In addition, appellants have failed to address the requirement                 
              for deposit of 1C2 hybridoma reference in claim 14.                                                        
                     It would appear that the appellants have failed to meet their burden in rebutting                   
              the examiner’s prima facie case of lack of enablement and, therefore, the rejection                        
              under 35 U.S.C. § 112, first paragraph for lack of enablement is sustained.                                
              35 U.S.C. § 112, second paragraph                                                                          
                     Claim 14 stands rejected under 35 U.S.C. § 112, second paragraph for failing to                     
              particularly point out and distinctly claim the subject matter which appellants regard as                  
              the invention.  The examiner states that claim 14 is indefinite due to the recitation of                   
              “either” in the claim, which renders the claim confusing.                                                  
                     The appellants acquiesce to this rejection.   Brief, page 5.                                        




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