Interference 102,413 Page 27
Pitha v. Muller
Pitha directed us to pages Sz-34 and Sz-36 to establish
that a portion of the product from Sz-8 was solubilized in
water with a drug. We have not been directed to evidence
which establishes a description of Sz-8 product or that the
Sz-8 product contained cyclodextrin derivatives. Thus, the
products Sz-34 and Sz-36, both of which incorporate Sz-8, do
not describe an embodiment which falls within the scope of the
count.
b. The product Sz-11 and products including Sz-11
In Sz-11 (PR 182, PX-19-20), the experiment took place no
later than July 2, 1981, which is the date indicated on the
subsequently occurring page PX-19-38. The reaction product of
BCD and 1,4 butanediol diglycidyl ether was said to be formed
during the experiment. The substance formed was described as
white and foam like with no homogenous composition of product.
There is no indication whether crystals were formed. There
was no indication whether the product of Sz-11 contained more
than one cyclodextrin derivative. The solubility of the
substance in water at room temperature is reported to be
3.60g/100ml. Dr. Szente states the solubility was improperly
recorded. 40
40PR page 182, lines 14-15.
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