LAGRANGE et al v. KONRAD et al - Page 23




                 Patent Interference No. 103,548                                                                                                  
                         A claimed invention is invalid for obviousness if the differences between it and                                         
                 the prior art "are such that the subject matter as a whole would have been obvious at                                            
                 the time the invention was made to a person having ordinary skill in the art." 35 U.S.C.                                         
                 § 103(a). "Invalidity based on obviousness is a question of law based on underlying                                              
                 facts. See Graham v. John Deere Co., 383 U.S. 1, 17-18, 148 USPQ 459, 467 (1966);                                                
                 Panduit Corp. v. Dennison Mfg. Co., 810 F.2d 1561, 1566-68, 1 USPQ2d 1593, 1595-                                                 
                 97 (Fed. Cir. 1987). The relevant facts relate to (1) the scope and content of the prior                                         
                 art, (2) the level of ordinary skill in the field of the invention, (3) the differences between                                  
                 the claimed invention and the prior art, and (4) any objective evidence of                                                       
                 nonobviousness such as long felt need, commercial success, the failure of others, or                                             
                 copying. Graham, 383 U.S. at 17, 148 USPQ at 467; see Continental Can Co. USA, Inc.                                              
                 v. Monsanto Co.,  948 F.2d 1264, 1270, 20 USPQ2d 1746, 1750-51 (Fed. Cir. 1991)."                                                
                 C.R. Bard Inc. v. M3 Systems Inc., 157 F.3d 1340, 48 USPQ2d 1225, 1231 (Fed. Cir.                                                
                 1998).                                                                                                                           
                 Scope and Content of Prior Art                                                                                                   
                         Konrad claims:                                                                                                           
                              · a genus of C1-4 alkyl-substituted indolines that covers a large number of                                         
                                  compounds;                                                                                                      
                              · and  a subgenus of methyl substituted indolines, i.e. C1 alkyl N-substituted                                      
                                  indoline;                                                                                                       
                              · an indoline structure that is the same as that of Lagrange; and,                                                  
                              · indolines are useful for dyeing hair.                                                                             
                         J. Chem. Soc. 1967 (which is cited in the Konrad '851 specification, at p. 3, lines                                      
                         9-10; copy attached) discloses:                                                                                          


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