Ex Parte HAGMANN et al - Page 8




               Appeal No. 2000-0634                                                                                              
               Application No. 08/274,942                                                                                        

               crosslinking energy in the process/apparatus of Clark would have been obvious to one of                           
               ordinary skill.  Thus, we uphold the Examiner’s rejection of claim 5.                                             
                      Because there is substantial evidence to support the Examiner’s determination of a                         
               prima facie case of obviousness over each of the applied prior art references, the burden of                      
               proof was properly shifted to the appellants to rebut the prima facie case by presenting                          
               persuasive argument or evidence (e.g., unexpected results).  In re Mayne, 104 F.3d 1339,                          
               1343, 41 USPQ2d 1451, 1455 (Fed. Cir. 1997).  (“With a factual foundation for its prima                           
               facie case of obviousness shown, the burden shifts to applicants to demonstrate that their                        
               claimed fusion proteins possess an unexpected property over the prior art.”).  Appellants                         
               have not sufficiently rebutted the prima facie case of obviousness.                                               
                                                         CONCLUSION                                                              
                      For the foregoing reasons and those set forth in the Answer, based on the totality of                      
               the record, we determine that the preponderance of evidence weighs in favor of obviousness,                       
               giving due weight to Appellants arguments.  Accordingly, the Examiner’s rejections under                          
               35 U.S.C. § 103(a) are affirmed.                                                                                  
                      The rejection of claims 1 to 4, 8 to 40, 42 to 61 and 63 to 81 under 35 U.S.C. § 103(a)                    
               as obvious over Clark is affirmed.                                                                                
                      The rejection of claim 5 under 35 U.S.C. § 103(a) as obvious over the combination of                       
               Clark and Fogarty is affirmed.                                                                                    
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