Ex Parte HOLTON et al - Page 6


                 Appeal No.  2000-1294                                                        Page 6                  
                 Application No.  08/850,924                                                                          
                 motivation to carve appellants’ claimed compounds from the genus disclosed by                        
                 Holton.                                                                                              
                        On this record, the examiner fails to identify any factual evidence                           
                 suggesting that a person of ordinary skill in the art would modify Holton, to obtain                 
                 appellants’ claimed invention.  Instead, as appellants point out (Reply Brief, page                  
                 2) C1-hydroxy compounds are the “most preferred alternative,” not the C1-deoxy                       
                 compounds claimed by appellants.  We remind the examiner as set forth in In re                       
                 Fritch, 972 F.2d 1260, 1266, 23 USPQ2d 1780, 1783 (Fed. Cir. 1992) (citations                        
                 omitted):                                                                                            
                        “Obviousness cannot be established by combining the teachings of                              
                        the prior art to produce the claimed invention, absent some                                   
                        teaching or suggestion supporting the combination.  Under section                             
                        103, teachings of references can be combined only if there is some                            
                        suggestion or incentive to do so.”  Although couched in terms of                              
                        combining teachings found in the prior art, the same inquiry must                             
                        be carried out in the context of a purported obvious “modification”                           
                        of the prior art.  The mere fact that the prior art may be modified in                        
                        the manner suggested by the Examiner does not make the                                        
                        modification obvious unless the prior art suggested the desirability                          
                        of the modification.”                                                                         
                        On the record before us, we find no suggestion to modify Holton as relied                     
                 upon by the examiner in a manner that would have reasonably led one of                               
                 ordinary skill in this art to arrive at the claimed invention.  The initial burden of                
                 presenting a prima facie case of obviousness rests on the examiner.  In re                           
                 Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444  (Fed. Cir. 1992).  In our                        
                 opinion the examiner failed to provide the evidence necessary to support a prima                     
                 facie case of obviousness.  Where the examiner fails to establish a prima facie                      
                 case, the rejection is improper and will be overturned.  In re Fine, 837 F.2d 1071,                  
                 1074, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988).                                                          





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