Ex Parte NORTHRUP et al - Page 5


               Appeal No. 2001-0062                                                                                                   
               Application 08/774,170                                                                                                 
               contain the biological material under analysis or test” (Column 15, lines 39-41).  Figure                              
               9 itself does not appear to show anything other than a splash-guard type of                                            
               arrangement.  See especially the oval shaped portions in the upper portion of Figure 9,                                
               which support the wall of the sample containment vessel above the reactive chip.                                       
               Further, the “vessel” is open.  This disclosure would not have suggested the invention                                 
               as claimed to one of ordinary skill in the art.   We do not see the sleeve reaction                                    
               chamber as required by Claim 1, nor the cell body having a cavity adjacent one of the                                  
               electrodes in claim 17, the only independent claims in this application.                                               
                       Where the Examiner fails to establish a prima facie case, the rejection is                                     
               improper and will be overturned.  In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596,                                      
               1598 (Fed. Cir. 1988).                                                                                                 
                       The rejection of Claims 1-5, 11, 14-18, and 24 under 35 U.S.C. §103 as being                                   
               unpatentable over Heller in view of Hall or Kamin is reversed.                                                         
               The Rejection of Claims 1-5, 14-18, and 24 Under 35 U.S.C. §103 over Pace in view of                                   
               Hall or Keller                                                                                                         
                       The Examiner states that Pace teaches a sleeve reaction chamber having slots                                   
               for communicating with entry holes for performing fluorescence reactions.  The slots are                               
               said to receive fluid directly from a buffer reservoir and sample chamber.  (Examiner’s                                
               Answer, page 6, lines 11-14, referencing Pace Figures 1-3, reference numerals 10, 20,                                  
               30 and 38).                                                                                                            
                       The Appellants state that the sleeve reaction chamber chamber including a slot                                 
               therein for insertion of reaction fluid is found nowhere in Pace, and is clearly not taught                            
               by channel 32 in Figure 3.                                                                                             


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