Ex Parte LUTJENS et al - Page 8


          Appeal No. 2001-2093                                                        
          Application No. 09/054,134                                                  

          temperatures and pH conditions appropriate for the process                  
          described in DE ’715 would have been within the level of the                
          ordinary skill in the art.  Boesch, 617 F.2d at 276, 205 USPQ at            
          219; Aller, 220 F.2d at 456, 105 USPQ at 235; Geisler, 116 F.3d             
          at 1469, 43 USPQ2d at 1365.                                                 
               The appellants argue that Günter aims to maintain low                  
          viscosity homogeneous reaction conditions, while DE ’715 relates            
          to insoluble polymeric reactants.  (Appeal brief, page 5; reply             
          brief filed Mar. 2, 2001, paper 27, pages 2-3.)  This argument              
          is not persuasive.  As we discussed above, one of ordinary skill            
          in the art would have known from the prior art that reaction                
          variables, such as temperature or pH conditions, are parameters             
          that must be taken into account in determining the appropriate              
          process conditions for alkylating tertiary amines, regardless of            
          whether the reactant is a compound or a polymer.  Buske, which              
          is discussed in detail in the reply brief (page 3), further                 
          supports this view.  (Column 6, lines 4-25.)                                
               The appellants urge that practicing the claimed process at             
          the recited temperatures and pH conditions overcomes “known                 
          difficulties.”  (Appeal brief, page 4.)  We note, however, that             
          the appellants’ position is not supported by sufficient                     
          evidence.  While the appellants rely on the declaration under 37            



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