Ex Parte BONI et al - Page 5



              Appeal No. 2001-2661                                                                 Page 5                
              Application No. 09/164,350                                                                                 
                     We have carefully reviewed the Examiner's Answer in its entirety, but find no                       
              plausible argument or evidence which would compensate for the deficiencies of                              
              Popescu, page 15, Example 2.  Again, the operative cooling step in that example is                         
              different and non-obvious from the incubating step in claim 1, performed "at a                             
              temperature above the temperature of the pretransition of the lipid component."                            
                     For the reasons succinctly stated in applicants' Appeal Brief and Reply Brief,                      
              amplified above, we reverse the rejections of claims 1 and 4 through 22 under 35                           
              U.S.C. § 102(a) and  35 U.S.C. § 103(a).  In so doing, we note that both applicants and                    
              the examiner have treated all of the claims as standing or falling together for the                        
              purposes of this appeal.  The examiner does not bifurcate process and product-by-                          
              process claims and treat them separately.  The examiner does not separately argue                          
              before us, that the products covered in applicants' product-by-process claims                              
              reasonably appear to be the same, or substantially the same, as the products prepared                      
              by Popescu, Example 2, even if Popescu's incubation temperature is different from                          
              applicants' temperature.  See In re Thorpe, 777 F.2d 695, 697, 227 USPQ 964, 966                           
              (Fed. Cir. 1985)(If the product in a product-by-process claim is the same as or obvious                    
              from a product of the prior art, the claim is unpatentable even though the prior product                   
              was made by a different process.)  Nor does the examiner controvert statements in                          
              applicants' specification that MLCVs prepared according to the present invention are                       
              characterized by several features that distinguish them from MLCVs made by prior art                       
              processes.  One particularly salient feature is the highly uniform distribution of                         
              biologically active compound among the MLCVs (instant specification, page 9, last                          
              paragraph).                                                                                                





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