Appeal No. 2001-2316 Page 2
Application No. 08/187,879
Claim 44 is illustrative of the subject matter on appeal and is reproduced
below:
44. A method of immunizing a mammal against an immunodeficiency
virus of interest selected from the group consisting of: simian
immunodeficiency virus and human immunodeficiency virus, said
method comprising administering to the mammal a DNA transcription
unit comprising DNA encoding an antigen of said immunodeficiency
virus of interest operatively linked to DNA which is a promoter region,
in a physiologically acceptable carrier, wherein the DNA transcription
unit is expressed in cells of the vertebrate, whereby the mammal is
protected from disease caused by said immunodeficiency virus of
interest.
The references relied upon by the examiner are:
Rekosh et al. (Rekosh), “Coexpression of human immunodeficiency virus
envelope proteins and tat from a single simian virus 40 late replacement vector,”
Proc. Natl. Acad. Sci., Vol. 85, pp. 334-338 (1988)
Hoffenback et al. (Hoffenback), “Unusually high frequencies of HIV-specific
cytotoxic T lymphocytes in humans,” J. Immunology, Vol. 142, pp. 452-462
(1989)
Johnson et al. (Johnson), “SIV Infection of Macaques as a Model for AIDS
Pathogenesis,” Intern. Rev. Immunol., Vol. 8, pp. 55-63 (1992)
(Kuby), Immunology p. 477 (Janis Kuby, ed., W.H. Freeman and Co., New York)
(1992)
Tang et al. (Tang), “Genetic immunization is a simple method for eliciting an
immune response,” Nature, Vol. 356, pp. 152-154 (1992)
Haynes, “Scientific and social issues of human immunodeficiency virus vaccine
development,” Science, Vol. 260, pp. 1279-1286 (1993)
Butini et al. (Butini), “Comparative analysis of HIV-specific CTL activity in
lymphoid tissue and peripheral blood,” J. Cellular Biochem., Suppl. 18B:147 Abst.
No. J306 (1994)
Gilboa et al. (Gilboa), “Gene therapy for infectious diseases: the AIDS model,”
TIG, Vol. 10, No. 4, pp. 139-144 (1994)
Glaser, “Biotech firms shift focus toward therapeutic HIV vaccine development,”
Genetic Engineering News, p. 6 (January 1, 1996)
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