Ex Parte LACKIE et al - Page 6




               Appeal No. 2001-2401                                                                                                
               Application 08/277,225                                                                                              
               specification would readily understand that no separation step is required.   Reply Brief,                          
               page 2.   In our view, with respect to the lack of a recited separation step in the claims,                         
               we find the examiner has not met his burden of proof by advancing acceptable                                        
               reasoning of indefiniteness.  For example, the examiner has made no reference to the                                
               specification indicating that such a separation step is required in the claimed method.                             
                       Moreover, we find that when the claim language, “portion of a tag,” is read in                              
               view of the disclosure, as required, its meaning is clear, and thus the metes and bounds                            
               of claim 1 are not indefinite.   For example, the specification pages 20 states ?Two                                
               signals are measured, one arising from the reference liquid and one arising from the                                
               sample.”  Specification, pages 20-21.   The phrase, “portion of a tag” would appear to                              
               refer to the tag retained on the solid phase upon formation of said first ligand/second                             
               ligand complex in the test sample.   It is to be compared with the tag retained on the                              
               solid phase using a known amount of analyte to determine the presence or level of the                               
               analyte in the sample.                                                                                              
                       In view of the above, the rejection of claims 1-10 under 35 U.S.C. § 112, second                            
               paragraph as being indefinite is reversed.                                                                          


               35 U.S.C. § 103                                                                                                     
                       Claims 1-5, 8-14, 16-21 and 23-25 stand rejected under 35 U.S.C. § 103 as                                   
               obvious over Pollema in view of Friguet and Woods.   Claims 6-7, 22 and 25 stand                                    
               rejected over the above combination of references, in further view of Freytag.                                      

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