Ex Parte PODUBRIN et al - Page 5




              Appeal No. 2002-0523                                                                                     
              Application No. 09/117,918                                                                               
                     We agree with appellants, that the examiner has failed to present sufficient                      
              evidence to support a prima facie case of obviousness.  Generally, "the discovery of an                  
              optimum value of a variable in a known process is normally obvious."  In re Antonie,                     
              559 F.2d 618, 619, 195 USPQ 6, 8 (CCPA 1977).  In re Boesch, 617 F.2d 272, 276,                          
              205 USPQ 215, 219 (CCPA 1980) (citing In re Antonie with approval).  The key to this                     
              rule is that the burden remains with the examiner to show that variable in question is                   
              "known to be result effective."  In re Antonie 559 F.2d at 621, 195 USPQ at 9.                           
              Exceptions to this rule have been found in cases where the results of optimizing a                       
              variable, which was known to be result effective, were unexpectedly good.  In re                         
              Waymouth, 499 F.2d 1273, 1276, 182 USPQ 290, 293 (CCPA 1974).  Another                                   
              exception is the case in which the parameter optimized was not recognized to be a                        
              result-effective variable.  See In re Antonie, 559 F.2d 618, 619, 195 USPQ 6, 8 CCPA                     
              1977).                                                                                                   
                     The examiner has argued that  “it is within the skill of the art to select optimal                
              parameters, such as amounts of ingredients, in a composition in order to achieve a                       
              beneficial effect.”  The examiner, however, has failed to provide evidence that both the                 
              optimal parameters or ratios claimed, and how to achieve the desired cosmetic or                         
              pharmaceutical beneficial effect were known in the art, or were known to be result                       
              effective variables.   For example, the examiner has not indicated how the optimal                       
              parameters for preparing an oil which can be used for margarine or an edible food                        
              relate to parameters necessary to obtain desired cosmetic or pharmaceutical benefit.                     

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