Appeal No. 2002-1355 Page 2
Application No. 08/907,783
and with a test compound, wherein the B cells act as co-stimulatory
molecules; and
determining whether the test compound induces a response
from the human naive T cells.
The examiner relies on the following references:
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vitro Test for Contact Allergens,” Int Arch Allergy Immunol, Vol. 106, pp. 394-400
(1995)
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using a modified lymphocyte transformation test,” Arch Toxicol, Vol. 70, pp. 414-
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Krasteva et al. (Krasteva), In vitro primary sensitization of hapten-specific T cells
by cultured human epidermal Langerhans cells – a screening predictive assay for
contact sensitizers,” Clinical and Experimental Allergy, Vol. 26, pp. 563-570
(1996)
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B Cell Interactions, Journal of Rheumatology, Vol. 19, No. 4, pp. 573-578 (1992)
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(1997)
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