Ex Parte STACHE et al - Page 3


                Appeal No. 2003-1034                                                  Page 3                 
                Application No. 08/897,455                                                                   


                record.  See In re Gartside, 203 F.3d 1305, 1315, 53 USPQ2d 1769, 1775 (Fed.                 
                Cir. 2000).                                                                                  
                      While we believe that one of the references cited by the examiner, the                 
                Djerassi reference, is relevant to the issue of the patentability of the claims, the         
                rejection ignores what appears to be a particularly pertinent teaching of that               
                reference.  Thus, we will first focus on the rejection over Djerassi, and then               
                address the rejections over Page, Bowers and Oughton.                                        
                      Claims 11, 12 and 14-17 stand rejected under 35 U.S.C. § 103(a) as being               
                obvious over Djerassi.  Due to its brevity, the rejection is set forth below:                

                            Djerassi [ ] teach[es] a generic group of 17,21-diesters of 6α,                  
                      16α-dimethyl-4-pregen-17α,21-diol-3,20-diones.  The reference                          
                      teaches acyl groups such as acetyl and phenylpropionyl, the                            
                      optional double bond in the 1-position and that the compounds                          
                      exhibit anti-inflammatory and glycogenic activity.                                     
                            The instant claims differ from the reference by reciting                         
                      specific species not exemplified by the reference, i.e., compounds                     
                      wherein R(1) is phenyl which may be substituted as indicated by                        
                      the claimed invention.  However, Djerassi teach[es] a variety of                       
                      specific acyl groups including phenylroprionyl attached to the 21                      
                      position.  Therefore, it would have been obvious to one of ordinary                    
                      skill in the art at the time of the present application to select any of               
                      the species of the genus taught by the reference, including those of                   
                      the instant claims, because he would have the reasonable                               
                      expectation that any species of the genus would have similar                           
                      properties, and, thus, the same use as the genus as a whole.  The                      
                      motivation to make the claimed compounds is based on the desire                        
                      to make additional compounds useful as taught by the prior art.                        
                Examiner’s Answer, pages 4-5 (citations omitted).                                            
                      The examiner’s rejection appears to be predicated on the proposition that              
                the description of a genus renders each and every species that are members of                
                the genus obvious.  Such a broad per se rule of obviousness, however, is not                 
                correct interpretation of the case law.  A broad disclosure of a genus does not              





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