Ex Parte BUECHLER et al - Page 7



              Appeal No. 2003-2084                                                                Page 7                
              Application No. 08/241,061                                                                                

              requires a representative sample of compounds and/or a showing of sufficient                              
              identifying characteristics; to demonstrate possession of the claimed generic(s)."                        
              Examiner's Answer, page 6.                                                                                
                     Appellants argue, inter alia:                                                                      
                            Moreover, Appellants respectfully submit that the specification as                          
                     filed clearly indicates to the skilled artisan that Appellants were in                             
                     possession of the claimed invention at the time of filing.  The specification                      
                     describes the common structural attributes shared by crosstalk inhibitors                          
                     as defined in the instant specification (i.e., that each is an analogue of a                       
                     linkage site), as well as common functional attributes shared by crosstalk                         
                     inhibitors (i.e., that each inhibits crosstalk caused by receptors that                            
                     recognize the linkage chemistry rather than the ligand).  The specification                        
                     follows this general description of the common structural and functional                           
                     attributes of crosstalk inhibitors by describing the synthesis of numerous                         
                     specific crosstalk inhibitors (see, e.g., examples 4-13 and 22).  Finally, the                     
                     specification also describes methods for testing the effectiveness of                              
                     crosstalk inhibitors in ligand-receptor assays (see, e.g., example 30).                            
              Appeal Brief, paragraph bridging pages 39-40.  In response, the examiner states:                          
                     Appellants [sic] arguments regarding the possession of the claimed                                 
                     composition at the time of filing have been considered, but are not                                
                     persuasive.  Appellants argue that the instant claimed composition                                 
                     comprise a mixture of ligand analogue conjugates, cross talk inhibitors                            
                     and ligand receptors.  It is noted that claim 98 composition does not have                         
                     the ligand receptor as in appellants [sic] argument.  Appellants assert that                       
                     the specification describes the common structural attributes shared by                             
                     cross talk [sic] inhibitors as defined, as well as common functional                               
                     attributes shared by cross talk [sic] inhibitors.  Appellants [sic] assertions                     
                     have been considered but are not persuasive.  The narrow scope of                                  
                     examples directed to specific crosstalk inhibitors are clearly not                                 
                     representative of the scope of the presently claimed composition.                                  
              Examiner's Answer, page 13, 2nd paragraph (emphasis in original).                                         
                     In considering the matter, we find ourselves in agreement with appellants'                         
              position again.  Appellants have carefully explained how the specification reasonably                     
              describes a genus of crosstalk inhibitors.  The examiner has focused upon the so-called                   
              "open ended claimed composition" (Examiner's Answer, page 5) and "narrow scope of                         




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