Appeal No. 2002-1545 Page 2
Application No. 08/949,757
galactose wherein 2-acetamido-2-deoxy-glucose and rhamnose are in
a 1:2 molar ratio.
36. An isolated Enterococcus antigen selected from the group consisting
of an E. faecalis antigen comprising 2-acetamido-2-deoxy-glucose,
rhamnose, glucose and 2-acetamido-2-deoxy-galactose, wherein 2-
acetamido-2-deoxy-glucose and rhamnose are in a 1:2 molar ratio, an
E. faecalis antigen comprising a trisaccharide repeat which comprises
a 6-deoxy sugar, and an E. faecium antigen comprising 2-acetamido-
2-deoxy-galactose and galactose.
The examiner relies upon the following references:
Foster et al. (Foster) 4,444,879 Apr. 24, 1984
Hawke et al. (Hawke) 5,641,390 Jun. 24, 1997
Blake et al. (Blake) 5,866,135 Feb. 2, 1999
Wessman, “Chemical Composition and Immunological Specificity of Cell Wall
Polysaccharide Group Antigens of Streptococcal Groups P and U,” Infection and
Immunity, Vol. 12, No.1, pp. 156-161 (1975)
Pritchard et al. (Pritchard), “Carbohydrate Fingerprints of Streptococcal Cells,”
Journal of Clinical Microbiology, Vol. 13, No. 1, pp.89-92 (1981)
Aluyi et al. (Aluyi), “Trimethylsilyl-sugar profiles of Streptococcus milleri and
Streptococcus mitis, Journal of Applied Bacteriology, Vol. 54, pp. 391-397 (1983)
Moreau et al. (Moreau), “Application of high-resolution N.M.R. spectroscopy to
the elucidation of the structure of the specific capsular polysaccharide of
Streptococcus pneumoniae Type 7F,” Carbohydrate Research, Vol. 182,
pp. 79-99 (1988)
Dick, Jr., et al. (Dick), “Glycoconjugates of Bacterial Carbohydrate Antigens,”
Conjugate Vaccines, Vol. 10, pp. 48-114 (1989)
Kitada et al. (Kitada), “Immunochemical characterization of the carbohydrate
antigens of serotype c/Lancefield group C ‘Streptococcus milleri’,” Oral Microbiol
Immunol., Vol. 8, pp.161-166 (1993)
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