Ex Parte Steiner et al - Page 6




                  Even if these findings were true, 7 they themselves would not                          
                  establish a prima facie case of obviousness.  As already                               
                  noted, a prima facie case requires a desirable reason to                               
                  modify a reference to reach the claimed invention.                                     
                        But in this rejection conspicuously absent from the                              
                  record is any reason to modify the teachings of *** [the PCT                           
                  application] to include, e.g., "an effective amount of a                               
                  heterocyclic compound" of the claimed invention.  Therefore,                           
                  the rejection is improper and should be reversed.                                      

                        21. The examiner provided a complete answer to                                   
            applicants' argument by referring in the Examiner's Answer                                   
            (Paper 12, page 4, line 1) to page 42 of the PCT application.                                
            There described are "pharmaceutical compositions comprising a                                
            therapeutically *** effective amount of the compound and a                                   
            pharmaceutically acceptable carrier or excipient" (PCT                                       
            application, page 42, lines 15-17). 8                                                        
                        22. Applicants in the Appeal Brief (Paper 11, page 3)                            
            argue as follows with respect to the examiner's rejection based                              
            on the PCT application:                                                                      
                        According to the Examiner, *** [Hamilton] discloses                              
                  compounds of some of the rejected claims and their use in                              
                  compositions.  Office action of 5/7/2, p. 2, ll. 14-17.                                
                  Even if these findings were true, 9 they themselves would not                          
                  establish a prima facie case of obviousness.  Neither urging                           

            7   In the Appeal Brief, applicants do not explain why "these findings" are                  
            wrong or otherwise are not supported by the evidence.                                        
            8   We believe applicants' sole argument for reversal with respect to the                    
            PCT application borders on frivolous.  In this respect, we note that no reply                
            brief was filed to respond to the Examiner's Answer.                                         
            9   See n.7.                                                                                 
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