Ex Parte EL KHOURY et al - Page 1



                           The opinion in support of the decision being entered today was not written                  
                                   for publication and is not binding precedent of the Board.                          

                                                                                           Paper No. 28                

                         UNITED STATES PATENT AND TRADEMARK OFFICE                                                     
                                                   __________                                                          

                              BEFORE THE BOARD OF PATENT APPEALS                                                       
                                            AND INTERFERENCES                                                          
                                                    __________                                                         
                           Ex parte GEORGE F. EL KHOURY and CHRISTOPH STEIN                                            
                                                    __________                                                         
                                               Appeal No. 2003-1765                                                    
                                             Application No. 09/319,735                                                
                                                    __________                                                         
                                                     ON BRIEF                                                          
                                                    __________                                                         
              Before SCHEINER, MILLS and GREEN, Administrative Patent Judges.                                          
              SCHEINER, Administrative Patent Judge.                                                                   
                                              DECISION ON APPEAL                                                       
                     This is a decision on appeal under 35 U.S.C. § 134 from the final rejection of                    
              claims 1-3, 5-9 and 11-22, the only claims remaining in the application.  Claims 1 and 8                 
              are representative of the subject matter on appeal:                                                      
                     1.  A method of inducing analgesia in inflamed skin or mucosal tissue,                            
              comprising topically administering to a patient in need of such treatment a topically                    
              effective amount of an opioid analgesic agent, which amount is systemically ineffective                  
              for induction of analgesia, admixed with a pharmaceutically acceptable excipient for                     
              topical administration, wherein said opioid is cyclazocone, piperidine, piperazine,                      
              pyrrolidine, morphiceptin, meperidine, trifluadom, benzeneacetamine, diacylacetamide,                    
              benzomorphan, hydromorphone, oxymorphone, levophanol, methadone, meperidine,                             
              fentanyl, codeine, hydrocodone, oxycodone, propoxyphene, buprenorphine,                                  
              butorphanol, pentazocine or nalbuphine.                                                                  
                     8.  A pharmaceutical composition comprising an admixture of an opioid analgesic                   
              agent and a pharmaceutically acceptable excipient for topical administration to inflamed                 
              skin or mucosal tissue, wherein                                                                          
                     a unit dosage amount of the admixture contains a systemically ineffective                         
              amount of the opioid analgesic agent, and                                                                



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