Ex Parte Mathur et al - Page 6


                 Appeal No. 2003-2017                                                         Page 6                    
                 Application No. 09/802,116                                                                             

                 fragments of SEQ ID NO:1 (original claim 1) as well as polynucleotides that,                           
                 among other things, hybridize to SEQ ID NO:1 under stringent conditions (claim                         
                 2).  These claims were rejected as anticipated.  See Paper No. 8, mailed Nov.                          
                 23, 2001.  In response, Appellants cancelled claim 2 and rewrote claim 1 in its                        
                 present form..  See Paper No. 9, filed Feb. 26, 2002.  Appellants stated that                          
                        as claim 1 has been amended to recite the complete nucleotide                                   
                        sequence of SEQ ID NO:1 . . . and claim 2 has been cancelled                                    
                        without prejudice and without disclaimer, Applicants submit that the                            
                        rejection of claims 1-2 under 35 U.S.C. § 102(a) has been                                       
                        overcome.                                                                                       
                 Id., page 10.  Thus, as the prosecution history makes clear, the language of the                       
                 claims on appeal does not allow for any variation in the recited sequences,2 even                      
                 though the open claim language allows for inclusion of additional sequence(s) at                       
                 the 3’ or 5’ end of the claimed polynucleotides.                                                       
                        The examiner rejected all of the elected claims for lack of utility.  The                       
                 examiner bears the initial burden of showing that a claimed invention lacks                            
                 patentable utility.  See In re Brana, 51 F.3d 1560, 1566, 34 USPQ2d 1436, 1441                         
                 (Fed. Cir. 1995) (“Only after the PTO provides evidence showing that one of                            
                 ordinary skill in the art would reasonably doubt the asserted utility does the                         
                 burden shift to the applicant to provide rebuttal evidence sufficient to convince                      
                 such a person of the invention’s asserted utility.”).                                                  


                                                                                                                        
                 the Examiner’s Answer, page 8.  Therefore, our conclusion with respect to the § 101 issue also         
                 applies to the § 112 issue.                                                                            
                 2 Thus, to the extent that the specification discusses NHP “homologs,” “domains,” “mutant              
                 versions”, hybridizing sequences, and functional equivalents (e.g., pages 3-5, 10-11, and 16-17),      
                 the present claims do not encompass those embodiments.                                                 





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