Ex Parte SADELAIN et al - Page 10


                Appeal No. 2004-1930                                                  Page 10                  
                Application No. 08/940,544                                                                     

                      actually shown to work.  Thus, this patent does not provide either                       
                      an enabling disclosure or a written description of applicants;                           
                      invention, but merely a generalized statement submitted to justify a                     
                      generic claim.                                                                           
                Id. at 9.                                                                                      
                      Appellants’ arguments are not convincing for the reasons set forth above                 
                to the response to argument with respect to the rejection over Eshhar.  While                  
                Roberts may not specifically exemplify scFv-containing fusions, it does exemplify              
                CD28 fusions.  Moreover, the reference teaches that, in particular, the                        
                extracellular domain may consist of monomeric or dimeric immunoglobulin (Ig)                   
                molecules or portions or modifications thereof.                                                
                      Finally, claims 1, 2, 6 and 7 stand rejected under 35 U.S.C. § 103(a) as                 
                being obvious over the combination of either Eshhar or Roberts and Sambrook.                   
                Because we have found that Eshhar and Roberts anticipate the invention of                      
                claim 1, and as the claims stand or fall together, see Appeal Brief, page 3, we                
                affirm the obviousness rejections as well.                                                     




















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