Ex Parte Naito - Page 4




               Appeal No. 2005-0126                                                                                              
               Application No. 09/967,791                                                                                        
               ocular, oral, otic rectal, vaginal, or upper respiratory mucosa, or through the skin or                           
               lungs.  Specification pages 4-5.                                                                                  

               35 U.S.C. §103(a)                                                                                                 
                      Claims 1-10 and 12-28 stand rejected under 35 U.S.C.  §103(a), as obvious in                               
               view of Naito and Keep.                                                                                           
                      In rejecting claims under 35 U.S.C. § 103, the examiner bears the initial burden                           
               of presenting a prima facie case of obviousness.  See In re Rijckaert, 9 F.3d 1531,                               
               1532, 28 USPQ2d 1955, 1956 (Fed. Cir. 1993).   It is well-established that the                                    
               conclusion that the claimed subject matter is prima facie obvious must be supported by                            
               evidence, as shown by some objective teaching in the prior art or by knowledge                                    
               generally available to one of ordinary skill in the art that would have led that individual to                    
               combine the relevant teachings of the references to arrive at the claimed invention.  See                         
               In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988).                                            
                      According to the examiner, “Naito teaches ingesting substances with a                                      
               combination of sugar and amino acid [hypertonic sugar composition] so that they                                   
               coexist in the blood stream and result in the facilitation of the use of the added material                       
               by the body...  The sugar/amino acid combination provides a vehicle and method for                                
               transporting substances across the blood-brain barrier (column 2, lines 2-4).”  Answer,                           
               page 5.   Naito exemplifies the administration of beta-carotene or xanthophylls with the                          
               sugar composition and indicates this composition has the effect of increasing the growth                          
               of hair and replacing grayness with original hair color.  Id.  Naito also teaches that any                        
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