Ex Parte LI et al - Page 7




              Appeal No. 2005-1516                                                                                     
              Application No. 09/182,645                                                                               
              ginseng hot water extract contains lignin glycoside.  Thus the examiner appears to                       
              argue that the teas of Wang and Ning (ginseng water extracts) provide lignin glycoside                   
              to the patient.                                                                                          
                     In our view the examiner has not met his burden of proof to establish a prima                     
              facie case of anticipation or provided any evidence that a water extract of ginseng                      
              contains a therapeutically effective amount of lignin glycoside.   The process of                        
              obtaining lignin glycoside as set forth both in the specification and in Tanuma 1 and 2 is               
              a multistep process.  As pointed out by appellants, lignin glycoside is not present in a                 
              hot water extract of a crude vegetative product (such as a pine cone, ginseng, etc.).                    
              Reply Brief, page 4.  Appellants argue that, Tanuma 1 discloses that the vegetative                      
              “material is treated in the solvent (for example, hot water, ethanol, acetone).  The                     
              treating time is about 1 to 15 hours.  The treated material is extracted in an alkaline                  
              solution (0.1 to 1N sodium hydroxide, ammonium, etc.).”  Tanuma 1, page 5, lines 5-12.                   
              We find no indication that the teas of Wang or Ning are steeped for 1-15 hours and,                      
              certainly, no teaching that the tea was extracted with an alkaline solution.                             
                     In addition, with respect to the teachings of Wang, we do not find that the                       
              examiner has provided any evidence that the diabetes patients described therein are                      
              patients having neural or cardiac tissue damage (claim 46), or that said patients suffer                 
              from any of the conditions recited in claims 47-49.  Thus, Wang does not reasonably                      
              appear to describe each element of the claimed method.                                                   
                     While Ning, unlike Wang, treats  patients suffering from ischemia (claim 47),                     

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